methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

Base Information

Chemical Name:methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate
CAS No.:148692-40-4
Molecular Formula:C₁₆H₂₁NO₅
Molecular Weight:307.346
Hs Code.:

Synonyms:methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

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Chemical Property of methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

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Technology Process of methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

There total 5 articles about methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 67-56-1
methanol

: tert-butyl (S)-(4-cyano-3-oxo-1-phenyl-4-(triphenyl-λ⁵-phosphanylidene)butan-2-yl)carbamate

: 148692-40-4
methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

Guidance literature:: With 3,3-dimethyldioxirane; In acetone; at 20 ℃; for 0.0833333h;
DOI:10.1021/jo0015974

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 148692-40-4
methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: EDCI; DMAP / CH₂Cl₂ / 20 °C

2: 62 percent / dimethyldioxirane / acetone / 0.08 h / 20 °C

With dmap; 3,3-dimethyldioxirane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetone;
DOI:10.1021/jo0015974

Reference yield:

: 820993-99-5
N-(tert-butyloxycarbonyl)-(2RS,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester

: 148692-40-4
methyl (S)-(t-butoxy carbonylamino)-2-oxo-4-phenylbutyrate

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Multistep reaction; 1.) CH₂Cl₂, -77 deg C, 20 min, 2.) CH₂Cl₂, -77 deg C, 10 min;
DOI:10.1021/jm00054a004