1-BROMO-3-METHYLADAMANTANE

Base Information

• Chemical Name: 1-BROMO-3-METHYLADAMANTANE
• CAS No.: 702-77-2
• Molecular Formula: C11H17Br
• Molecular Weight: 229.16
• Hs Code.: 2903890090
• Mol file: 702-77-2.mol

Synonyms:NSC 255329;Adamantane,1-bromo-3-methyl- (7CI,8CI);1-Bromo-3-methyladamantane;1-Methyl-3-bromoadamantane;

Chemical Property of 1-BROMO-3-METHYLADAMANTANE

Chemical Property:

• Vapor Pressure: 0.0497mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 243.6 °C at 760 mmHg
• Flash Point: 103.7 °C
• PSA: 0.00000
• Density: 1.403 g/cm³
• LogP: 3.74020
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility.: Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-3-methyladamantane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate int he preparation of Memantine derivatives.

Technology Process of 1-BROMO-3-METHYLADAMANTANE

There total 4 articles about 1-BROMO-3-METHYLADAMANTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-adamantane (768-91-2) → 1-bromo-3-methyladamantane (702-77-2)

Guidance literature:

With bromine; at 0 - 20 ℃; for 2h; Heating / reflux;

Reference yield: 85.0%

3-methyl-1-adamantanol (702-81-8) → 1-bromo-3-methyladamantane (702-77-2)

Guidance literature:

With bromine; triphenylphosphine; In acetonitrile; for 30h; Heating;

DOI:10.1021/jm00343a010

Reference yield: 44.0%

1,3-dibromoadamantane (876-53-9) + methylmagnesium bromide (75-16-1) → 1,3-dimethyladamantane (702-79-4) + adamantane (281-23-2) + 1-bromo-3-methyladamantane (702-77-2)

Guidance literature:

In dibutyl ether; at 140 ℃;

upstream raw materials:

1-methyl-adamantane

1,3-dibromoadamantane

methylmagnesium bromide

3-methyl-1-adamantanol

Downstream raw materials:

3-methyl-1-adamantanol

1-acetamido-3-methyltricyclo[3.3.1.1^3,7]decane

1,3-dimethyladamantane

1-methyl-3-phenyladamantane

Refernces

• 1、 -. "AMINO ADAMANTANE DERIVATIVES, METHODS FOR THE PRODUCTION AND USE THEREOF". Page/Page column 54-55. . Retrieved 2010/02/15.
• 2、 Henkel, James G.,Hane, Jeffrey T.,Gianutsos, Gerald. "Structure-Anti-Parkinson Activity Relationships in the Aminoadamantanes. Influence of Bridgehead Substitution". . p. 51 - 56. Retrieved 2007/10/02.