2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

Base Information

• Chemical Name: 2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide
• CAS No.: 1100799-18-5
• Molecular Formula: C₁₇H₁₉N₅O₄S
• Molecular Weight: 389.435

Synonyms:2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

Chemical Property of 2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

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Technology Process of 2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide

There total 1 articles about 2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide (134477-88-6) → 2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide (1100799-18-5)

Guidance literature:

In 1,4-dioxane; for 3h; Reflux;

DOI:10.1002/jhet.5570450641

Reference yield: 30.0%

2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide (1100799-18-5) + phenylhydrazine (100-63-0) → N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-5-methyl-N,1-diphenyl-1H-pyrazole-4-carbohydrazonamide (1100799-32-3)

Guidance literature:

In ethanol; for 8h; Reflux;

DOI:10.1002/jhet.5570450641

Reference yield:

Cyanothioacetamide (7357-70-2) + 2-acetyl-3-(dimethylamino)-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}acrylamide (1100799-18-5) → 5-cyano-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide (1100799-28-7)

Guidance literature:

With piperidine; In ethanol; for 6h; Reflux;

DOI:10.1002/jhet.5570450641

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

3-oxo-N-{4-[(pyrimidin-2-ylamino)sulphonyl]phenyl}butanamide

Downstream raw materials:

5-cyano-2-methyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-6-thioxo-1,6-dihydropyridine-3-carboxamide

4-(3,5-diacetyl-6-hydroxy-2-oxo-2H-pyridin-1-yl)-N-pyrimidin-2-ylbenzene-sulfonamide

5-acetyl-2-amino-6-oxo-1-{4-[(pyrimidin-2-ylamino)sulfonyl]-phenyl}-1,6-dihydropyrimidine-3-carboxylic acid ethyl ester

N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}-5-methyl-N,1-diphenyl-1H-pyrazole-4-carbohydrazonamide

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