5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester
CAS No.:159693-10-4
Molecular Formula:C₁₄H₉F₆NO₃
Molecular Weight:353.221
Hs Code.:

Synonyms:5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Suppliers and Price of 5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

There total 3 articles about 5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.3%

: 79424-03-6
ethyl 4,4,4-trifluoro-2-butynate

: 74467-05-3
N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

: 159693-10-4
5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: With sodium hydroxide; In dichloromethane; at -5 - 5 ℃; for 0.25h;
DOI:10.1021/jf00049a040

Reference yield:

: 74467-05-3
N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

: 893643-18-0
5,5,5-trifluoro-2,4-dioxopentanoic acid ethyl ester

: 159693-10-4
5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2017.06.028

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 159693-10-4
5-Trifluoromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 66.3 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

With sodium hydroxide; N-chloro-succinimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040