3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid

Base Information

Chemical Name:3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid
CAS No.:883543-16-6
Molecular Formula:C₁₂H₅F₆NO₃
Molecular Weight:325.167
Hs Code.:

Synonyms:3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid

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Chemical Property of 3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid

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Technology Process of 3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid

There total 3 articles about 3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66046-34-2
4-(trifluoromethyl)benzaldehyde oxime

: 883543-16-6
3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-chlorosuccinimide / dimethylformamide / Ambient temperature

2: 66.3 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

3: conc. aq. HCl, CH₃COOH / 72 h / Heating

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; acetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jf00049a040

Reference yield:

: 74467-05-3
N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride

: 883543-16-6
3-(4-trifluoromethylphenyl)-5-trifluoromethylisoxazol-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 66.3 percent / 5percent aq. NaOH / CH₂Cl₂ / 0.25 h / -5 - 5 °C

2: conc. aq. HCl, CH₃COOH / 72 h / Heating

With hydrogenchloride; sodium hydroxide; acetic acid; In dichloromethane;
DOI:10.1021/jf00049a040