{5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

Base Information

Chemical Name:{5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol
CAS No.:1027521-19-2
Molecular Formula:C₂₀H₁₈Cl₂N₂O₄
Molecular Weight:421.28
Hs Code.:

Synonyms:{5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

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Chemical Property of {5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

Chemical Property:

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Technology Process of {5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

There total 1 articles about {5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 850221-88-4
2,3-dichloro-5-(1-hydroxy-[4-methoxyphenyl]methyl)pyrazine

: 123-11-5
4-methoxy-benzaldehyde

: 1027521-19-2
{5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

Guidance literature:: 2,3-dichloro-5-(1-hydroxy-[4-methoxyphenyl]methyl)pyrazine; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-methoxy-benzaldehyde; With hexachloroethane; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1021/jo0478196

Reference yield:

: 1027521-19-2
{5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

: 850221-89-5
2,3-dichloro-5,6-di-(1-oxo-[4-methoxyphenyl]methyl)pyrazine

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jo0478196

Reference yield:

: 1027521-19-2
{5,6-dichloro-3-[hydroxy-(4-methoxy-phenyl)-methyl]-pyrazin-2-yl}-(4-methoxy-phenyl)-methanol

: 850221-91-9
(5-(4-methoxyphenyl)pyrazine-2,3-diyl)bis((4-methoxyphenyl)-methanone)

Guidance literature:: Multi-step reaction with 3 steps

1: 1.76 g / MnO₂ / tetrahydrofuran / 12 h / 20 °C

2: 70 percent / aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / 8 h / Heating

3: 75 percent / HCOOH; Et₃N / Pd/C / acetone / 3 h / Heating

With manganese(IV) oxide; formic acid; potassium carbonate; triethylamine; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; acetone; toluene; 2: Suzuki reaction;
DOI:10.1021/jo0478196