tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313441-51-8
Molecular Formula:C₂₇H₂₉N₃O₄S
Molecular Weight:491.611
Hs Code.:

Synonyms:tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

There total 6 articles about tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 6165-69-1
Thien-3-ylboronic acid

: 1313441-49-4
tert-butyl (1-(4-(7-bromo-1-methyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

: 1313441-51-8
tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: With triphenylphosphine; cesium fluoride; palladium diacetate; In 1,2-dimethoxyethane; at 20 - 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 105544-36-3
7-bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one

: 1313441-51-8
tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3: bis(dimethylphosphino)palladium(IV) chloride / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

4: cesium fluoride; triphenylphosphine / palladium diacetate / 1,2-dimethoxyethane / 18 h / 20 - 80 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; triphenylphosphine; cesium fluoride; bis(dimethylphosphino)palladium(IV) chloride; palladium diacetate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 1032350-06-3
tert-butyl (1-(4-bromophenyl)cyclobutyl)carbamate

: 1313441-51-8
tert-butyl (1-(4-(1-methyl-2-oxo-7-(thiophen-3-yl)-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / Inert atmosphere; Reflux

2: bis(dimethylphosphino)palladium(IV) chloride / N,N-dimethyl-formamide / 20 - 80 °C / Inert atmosphere

3: cesium fluoride; triphenylphosphine / palladium diacetate / 1,2-dimethoxyethane / 18 h / 20 - 80 °C / Inert atmosphere

With triphenylphosphine; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(dimethylphosphino)palladium(IV) chloride; palladium diacetate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene;