4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one

Base Information

• Chemical Name: 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one
• CAS No.: 885263-37-6
• Molecular Formula: C₂₆H₂₄O₆
• Molecular Weight: 432.473
• Mol file: 885263-37-6.mol

Synonyms:4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one

Chemical Property of 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one

There total 24 articles about 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

1-bromo-4-methoxy-benzene (104-92-7) + 3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2,3-dihydro-1H-inden-1-one (1266555-80-9) → 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one (885263-37-6) + trans-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one + cis-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one + 3-(3,5-dimethoxyphenyl)-2-hydroxy-4,6-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-inden-1-one

Guidance literature:

With palladium diacetate; sodium t-butanolate; XPhos; In tetrahydrofuran; at 80 ℃; for 3h;

DOI:10.1021/jo2009164

Reference yield: 72.0%

(E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol (1001258-87-2) → 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one (885263-37-6)

Guidance literature:

(E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol; palladium diacetate; copper diacetate; In isopropyl alcohol; at 25 - 60 ℃; for 5h;

With hydrogenchloride; In isopropyl alcohol; at 25 ℃; for 16h; Product distribution / selectivity;

Reference yield: 70.0%

1-(3,5-dimethoxyphenyl)-5,7-dimethoxy-2-(4-methoxyphenyl)-2,3-dihydro-1H-indene → 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one (885263-37-6)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; at 110 ℃; for 30h;

DOI:10.1002/anie.201711797

upstream raw materials:

(2R,3R)-3-(3,5-Dimethoxy-phenyl)-4,6-dimethoxy-2-(4-methoxy-phenyl)-indan-1-one

C₂₆H₂₆O₆

(Z)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-1-(4-methoxybenzylidene)-1,3-dihydro-isobenzofuran

(E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol

Downstream raw materials:

C₂₁H₁₄O₆