1001258-87-2

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 676596-82-0 (E)-2-bromo-1,5-dimethoxy-3-(4-methoxystyryl)benzene 
• 81574-69-8 2-bromo-4,6-dimethoxybenzaldehyde 
• 906457-43-0 (E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde 
• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 637-69-4 4-Methoxystyrene 
• 22255-22-7 3,5,4'-trimethoxy-trans-stilbene 
• 322640-05-1 3,5-dimethoxyphenyl magnesium bromide 

Downstream Products

• 1001259-14-8 (E)-(2,4-dimethoxy-6-(4-methoxystyryl)phenyl)(3,5-dimethoxyphenyl)methanone 
• 1133711-30-4 C₂₇H₃₀O₆ 
• 1111942-67-6 C₂₆H₂₆O₆ 
• 1133711-28-0 (Z)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-1-(4-methoxybenzylidene)-1,3-dihydro-isobenzofuran 
• 885263-37-6 4,6-dimethoxy-3-(3,5-dimethoxyphenyl)-2-(4-methoxyphenyl)-1H-inden-1-one 
• 1111942-66-5 C₂₆H₂₆O₆ 
• 1111942-45-0 C₃₄H₃₆O₆S 
• 1133711-34-8 C₂₆H₂₆O₆ 
• 1377399-63-7 C₅₆H₄₆O₆ 

Relevant academic research and scientific papers

Selective Divergent Synthesis of Indanols, Indanones, and Indenes via Acid-Mediated Cyclization of (Z)- and (E)-(2-Stilbenyl)methanols and Its Application for the Synthesis of Paucifloral F Derivatives

Starting from bromo/iodobenzaldehyde derivatives, the corresponding (Z)- and (E)-(2-stilbenyl)methanols could be prepared in 2-5 steps via Pd-catalyzed cross-coupling reactions (Sonogashira and Heck reactions) followed by aryllithium/aryl Grignard addition. For the (E)-stilbenes, subsequent acid-mediated cyclization using p-TsOH immobilized on silica (PTS-Si) at low temperatures furnished the 2,3-trans-1-indanols with complete stereocontrol at the C2-C3. Further oxidization of the alcohol provided the indanones, which are structurally related to the natural product paucifloral F. At higher temperatures, 1,2- and 2,3-disubstituted indenes could be selectively prepared in good to excellent yields. On the other hand, the (Z)-stilbenes, under similar conditions (PTS-Si), did not give the indanols; only the 1,2-disubstituted indenes could be obtained. To gain further insights into the stereochemistry at C2-C3 for the (Z)-stilbenes, hydride or azide was employed as a nucleophile; the corresponding indane products were obtained with the cis stereochemistry at the C2-C3. Thus, the (Z)- or (E)-olefin geometry of the substrate directed the stereoselective indanyl cyclization to furnish the cis or trans at the C2-C3 ring junction, respectively, while reaction conditions controlled the selectivity of the product types.

Palladium-Catalyzed Intramolecular Trost–Oppolzer-Type Alder–Ene Reaction of Dienyl Acetates to Cyclopentadienes

A new approach to the synthesis of highly substituted cyclopentadienes, indenes, and cyclopentene-fused heteroarenes by means of the Pd-catalyzed Trost–Oppolzer-type intramolecular Alder–ene reaction of 2,4-pentadienyl acetates is described. This unpreced

RESVERATROL-BASED COMPOUNDS

The invention provides a compound having the structure compound having the structure: Formula wherein bond a is present or absent, wherein when bond a is absent, then bond β is: Sign (I) and R1 is: Formula and when bond a is present, then Rsub

Total syntheses of hopeanol and hopeahainol a empowered by a chiral br?nsted acid induced pinacol rearrangement

Rearranging complexity: The total synthesis of resveratrol dimers hopeanol (1) and hopeahainolA (2, see scheme) is described. By using a reagent-driven pinacol rearrangement coupled with specific oxidation chemistry, the frameworks are constructed concisely and on scale. Moreover, the route has biogenetic implications that trace the origin of these compounds to more common dimeric family members. Copyright

Modular synthesis of polyphenolic benzofurans, and application in the total synthesis of malibatol A and shoreaphenol

A modular strategy for the synthesis of hexacyclic dimeric resveratrol polyphenolic benzofurans is reported. The developed synthetic technology was applied to the total synthesis of malibatol A, shoreaphenol, and other biologically relevant polyphenols.

Total synthesis of diverse carbogenic complexity within the resveratrol class from a common building block

Although biomimetic approaches have proven capable of converting resveratrol (1) concurrently into many of the more complex oligomers produced by plants throughout the world (such as 2-10), methods to access single members of the family have proven far more difficult to identify. Herein is described a strategy-level solution based on the use of a common building block, one distinct from Nature's starting material, that can participate in a variety of highly selective, reagent-controlled reaction cascades. These endeavors have led to the controlled synthesis of 25 natural products and analogues, molecules whose architectures encompass nearlyall the carbogenic diversity of the resveratrol family.

SYNTHESIS OF RESVERATROL-BASED NATURAL PRODUCTS

Processes for synthesizing reveratrol-based oligomers are provided. In addition, reservatrol-based oligomer compounds free of plant extract are provided.

Total synthesis of resveratrol-based natural products: A chemoselective solution

Despite the attention paid to resveratrol (1) owing to its potent biological activity, little effort has been devoted to studying resveratrol-based oligomers (such as 2-4). The first general synthetic approach is outlined for accessing the carbogenic diversity possessed by this family of compounds. (Chemical Equation Presented).