(E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol

Base Information

• Chemical Name: (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol
• CAS No.: 1001258-87-2
• Molecular Formula: C₂₆H₂₈O₆
• Molecular Weight: 436.505
• Mol file: 1001258-87-2.mol

Synonyms:(E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol

Chemical Property of (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol

There total 6 articles about (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3,5-dimethoxybenzaldehdye (7311-34-4) + (E)-2-bromo-1,5-dimethoxy-3-(4-methoxystyryl)benzene (676596-82-0) → (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol (1001258-87-2)

Guidance literature:

(E)-2-bromo-1,5-dimethoxy-3-(4-methoxystyryl)benzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.416667h; Inert atmosphere;

3,5-dimethoxybenzaldehdye; In tetrahydrofuran; at -78 - 25 ℃; Inert atmosphere;

Reference yield: 62.0%

(E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde (906457-43-0) + 1-bromo-3,5-dimethoxybenzene (20469-65-2) → (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol (1001258-87-2)

Guidance literature:

1-bromo-3,5-dimethoxybenzene; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

(E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.8b01921

Reference yield:

(E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde (906457-43-0) + 3,5-dimethoxyphenyl magnesium bromide (322640-05-1) → (E)-[2,4-dimethoxy-6-(4-methoxystyryl)phenyl]-(3,5-dimethoxyphenyl)methanol (1001258-87-2)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.3390/molecules15095909

upstream raw materials:

3,5-dimethoxybenzaldehdye

(E)-2-bromo-1,5-dimethoxy-3-(4-methoxystyryl)benzene

(E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde

3,5-dimethoxyphenyl magnesium bromide

Downstream raw materials:

(E)-(2,4-dimethoxy-6-(4-methoxystyryl)phenyl)(3,5-dimethoxyphenyl)methanone

C₂₇H₃₀O₆

C₂₆H₂₆O₆

(Z)-3-(3,5-dimethoxyphenyl)-4,6-dimethoxy-1-(4-methoxybenzylidene)-1,3-dihydro-isobenzofuran