5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Base Information

• Chemical Name: 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide
• CAS No.: 1617518-24-7
• Molecular Formula: C₁₆H₁₄ClNO₅S
• Molecular Weight: 367.81

Synonyms:5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Chemical Property of 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

Chemical Property:

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Technology Process of 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

There total 4 articles about 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

5-chloro-N-(1,1-dioxo-1H-1λ6-benzo[b]thiophen-6-yl)-2-hydroxybenzamide (1430330-65-6) → 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]thiophen-6-yl)-2-hydroxybenzamide (1617518-24-7)

Guidance literature:

With water; sodium hydroxide; In methanol; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.05.049

Reference yield: 30.0%

methanol (67-56-1) + 5-chloro-N-(1,1-dioxo-1H-1λ6-benzo[b]thiophen-6-yl)-2-hydroxybenzamide (1430330-65-6) → 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]thiophen-6-yl)-2-hydroxybenzamide (1617518-24-7)

Guidance literature:

With sodium hydroxide; at 0 - 20 ℃; for 0.25h;

Reference yield:

5-chloro-2-hydroxybenzoyl chloride (15216-81-6) → 5-chloro-N-(3-methoxy-1,1-dioxo-2,3-dihydro-1H-1λ6-benzo[b]thiophen-6-yl)-2-hydroxybenzamide (1617518-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

1.2: 21915 h / 0 °C

2.1: sodium hydroxide / 0.25 h / 0 - 20 °C

With pyridine; sodium hydroxide; In N,N-dimethyl-formamide;

upstream raw materials:

5-chloro-2-hydroxybenzoyl chloride

methanol

5-chloro-N-(1,1-dioxo-1H-1λ⁶-benzo[b]thiophen-6-yl)-2-hydroxybenzamide

5-chloro-2-hydroxybenzoic acid

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