[(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Base Information

Chemical Name:[(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester
CAS No.:1350636-75-7
Molecular Formula:C₁₁H₂₁NO₃S
Molecular Weight:247.359
Hs Code.:

Synonyms:[(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Suppliers and Price of [(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 4 raw suppliers

Chemical Property of [(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

There total 16 articles about [(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350636-89-3
{(1R,2R,4R)-4-[(tert-butoxycarbonyl)amino]-2-hydroxycyclohexyl}phenyl thioformate

: 1350636-75-7
[(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Guidance literature:: With DL-dithiothreitol; hydrazine hydrate; In dichloromethane; at 18 - 22 ℃; for 3h; Industry scale;

Reference yield:

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

: 1350636-75-7
[(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 0.58 h / 20 - 95 °C / Reflux

2: copper(l) chloride / 0.83 h / 80 - 100 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 15 - 40 °C / Industry scale

4: tetrabutyl-ammonium chloride / toluene / 4 h / 30 - 45 °C / Industry scale

5: hydrazine hydrate; DL-dithiothreitol / dichloromethane / 3 h / 18 - 22 °C / Industry scale

With DL-dithiothreitol; diphenyl phosphoryl azide; hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrabutyl-ammonium chloride; copper(l) chloride; In dichloromethane; toluene; 1: Curtius Rearrangement;

Reference yield:

: 1350636-88-2
(1R,3R,6S)-(7-oxabicyclo[4.1.0]hept-3-yl)carbamic acid tert-butyl ester

: 1350636-75-7
[(1R,3R,4R)-3-hydroxy-4-mercaptocyclohexyl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride / toluene / 4 h / 30 - 45 °C / Industry scale

2: hydrazine hydrate; DL-dithiothreitol / dichloromethane / 3 h / 18 - 22 °C / Industry scale

With DL-dithiothreitol; hydrazine hydrate; tetrabutyl-ammonium chloride; In dichloromethane; toluene;