C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾

Base Information

• Chemical Name: C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾
• CAS No.: 1316844-34-4
• Molecular Formula: C₂H₃O₂*C₂₀H₁₉INO₂
• Molecular Weight: 491.325
• Mol file: 1316844-34-4.mol

Synonyms:C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾

Chemical Property of C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾

There total 2 articles about C₂H₃O₂^(1-)*C₂₀H₁₉INO₂⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

[bis(acetoxy)iodo]benzene (3240-34-4) + ethyl 2-methyl-5-phenyl-1H-pyrrole-1-carboxylate (1316844-22-0) → C2H3O2(1-)*C20H19INO2(1+) (1316844-34-4)

Guidance literature:

With acetic acid; at 20 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1021/ol201665c

Reference yield:

2-methyl-5-phenyl-1H-pyrrole (3042-21-5) → C2H3O2(1-)*C20H19INO2(1+) (1316844-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 1 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: acetic acid / 18 h / 20 °C / Inert atmosphere

With sodium hydride; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/ol201665c

Reference yield: 73.0%

C2H3O2(1-)*C20H19INO2(1+) (1316844-34-4) → ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate (1316844-47-9)

Guidance literature:

With palladium diacetate; acetic acid; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol201665c

upstream raw materials:

2-methyl-5-phenyl-1H-pyrrole

[bis(acetoxy)iodo]benzene

ethyl 2-methyl-5-phenyl-1H-pyrrole-1-carboxylate

Downstream raw materials:

ethyl 3-(acetyloxy)-2-methyl-5-phenyl-1H-pyrrole-1-carboxylate