trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Base Information

Chemical Name:trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide
CAS No.:1319743-29-7
Molecular Formula:C₂₃H₂₁Cl₂F₃N₂O₂
Molecular Weight:485.333
Hs Code.:

Synonyms:trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

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Chemical Property of trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

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Technology Process of trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

There total 5 articles about trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17630-75-0
5-chloro-indolin-2-one

: 1207529-71-2
trifluoro-methanesulfonic acid trans-4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexylmethyl ester

: 1319743-29-7
trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Guidance literature:: 5-chloro-indolin-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

trifluoro-methanesulfonic acid trans-4-(2-chloro-5-trifluoromethyl-benzoylamino)-cyclohexylmethyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 657-05-6
2-chloro-5-trifluoromethylbenzoyl chloride

: 1319743-29-7
trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1.83 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2.2: 0 °C

3.1: pyridine / dichloromethane / 1 h / 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.2: 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 61367-07-5,61367-16-6,100707-54-8
trans-4-aminocyclohexylcarboxylic acid methyl ester hydrochloride

: 1319743-29-7
trans-2-chloro-N-[4-(5-chloro-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-5-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1.83 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2.2: 0 °C

3.1: pyridine / dichloromethane / 1 h / 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C

4.2: 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;