Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-

Base Information

• Chemical Name: Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-
• CAS No.: 37885-07-7
• Molecular Formula: C9H8 F3 N O
• Molecular Weight: 203.164
• Hs Code.: 2922399090
• Mol file: 37885-07-7.mol

Synonyms:1-(2-Amino-4-trifluoromethylphenyl)ethanone;2'-Amino-4'-(trifluoromethyl)acetophenone

Chemical Property of Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-

Chemical Property:

• Vapor Pressure: 0.00554mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 274℃
• PKA: 1.08±0.10(Predicted)
• Flash Point: 120℃
• PSA: 43.09000
• Density: 1.296
• LogP: 3.07140
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99.90% ^*data from raw suppliers

1-(2-Amino-4-(trifluoromethyl)phenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]-

There total 5 articles about Ethanone,1-[2-amino-4-(trifluoromethyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-nitro-4-trifluoromethyl-acetophenone (128403-22-5) → 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone (37885-07-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 0.5h;

Reference yield:

2-amino-4-trifluoromethylbenzonitrile (1483-54-1) + methylmagnesium chloride (676-58-4) → 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone (37885-07-7)

Guidance literature:

With water; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.8b01615

Reference yield:

C9H16N2*C9H6F3N2O4(1-)*H(1+) → 1-(2-amino-4-(trifluoromethyl)phenyl)ethanone (37885-07-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂O₂, K₂CO₃ / toluene; H₂O

2: 95 percent / NH₄HCO₂ / 5percent Pd/C / methanol / Heating

With dihydrogen peroxide; ammonium formate; potassium carbonate; palladium on activated charcoal; In methanol; water; toluene;

DOI:10.1016/S0040-4039(00)88734-1

upstream raw materials:

2-nitro-4-trifluoromethyl-acetophenone

2-amino-4-trifluoromethylbenzonitrile

methylmagnesium chloride

Downstream raw materials:

N-(2-Acetyl-5-trifluoromethyl-phenyl)-formamide

N-[(3-fluorophenyl)-methyl]-4-methyl-2-oxo-1-(tetrahydro-pyran-4-yl)-7-(trifluoromethyl)-1H-quinoline-3-carboxylic acid amide

ethyl 3-((2-acetyl-5-(trifluoromethyl)phenyl)(tetrahydro-2H-pyran-4-yl)amino)-3-oxopropanoate

3-methyl-6-trifluoromethyl-1H-indole

Refernces

• 1、 Xia, Hai-Dong,Zhang, Yan-Dong,Wang, Yan-Hui,Zhang, Chi. "Water-Soluble Hypervalent Iodine(III) Having an I-N Bond. A Reagent for the Synthesis of Indoles". supporting information. p. 4052 - 4056. Retrieved 2018/07/15.
• 2、 -. "Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives". Page/Page column 37; 10/12. . Retrieved 2010/10/20.