2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid

Base Information

• Chemical Name: 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid
• CAS No.: 1092718-61-0
• Molecular Formula: C₂₀H₂₂N₂O₈
• Molecular Weight: 418.403
• Mol file: 1092718-61-0.mol

Synonyms:2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid

Chemical Property of 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid

There total 2 articles about 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-butyl-(4-chloro-3-nitrophenyl)carboxamide (59320-12-6) + 4-hydroxy-3-methoxy-mandelic acid (55-10-7,2394-20-9) → 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid (1092718-61-0)

Guidance literature:

N-butyl-(4-chloro-3-nitrophenyl)carboxamide; 4-hydroxy-3-methoxy-mandelic acid; With caesium carbonate; In dimethyl sulfoxide; at 60 ℃; for 4h;

With hydrogenchloride; water; In dimethyl sulfoxide; pH=3;

DOI:10.1021/jo8021499

Reference yield:

4-chloro-3-nitro-benzoyl chloride (38818-50-7) → 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid (1092718-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 20 °C

2: caesium carbonate / dimethyl sulfoxide / 72 h / 60 °C

With caesium carbonate; triethylamine; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2011.10.123

Reference yield: 96.0%

methanol (67-56-1) + 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetic acid (1092718-61-0) → methyl 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetate (1092718-57-4)

Guidance literature:

With sulfuric acid; at 50 ℃; for 3h;

DOI:10.1021/jo8021499

upstream raw materials:

N-butyl-(4-chloro-3-nitrophenyl)carboxamide

4-hydroxy-3-methoxy-mandelic acid

4-chloro-3-nitro-benzoyl chloride

Downstream raw materials:

methyl 2-(4-(4-(butylcarbamoyl)-2-nitrophenoxy)-3-methoxyphenyl)-2-hydroxyacetate

C₂₆H₂₄Cl₂F₂N₂O₇S

C₂₁H₂₂F₂N₂O₇

C₂₁H₂₄F₂N₂O₅