4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Base Information

Chemical Name:4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile
CAS No.:1464151-16-3
Molecular Formula:C₂₅H₂₁N₇O₃
Molecular Weight:467.487
Hs Code.:

Synonyms:4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Suppliers and Price of 4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

There total 8 articles about 4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1464154-95-7
(4-bromo-2-nitrophenyl)(4-methylpiperazin-1-yl)methanone

: 4-(6-chloroimidazo[1,2-a]pyrazin-3-yl)benzonitrile

: 1464151-16-3
4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: (4-bromo-2-nitrophenyl)(4-methylpiperazin-1-yl)methanone; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; bis(pinacol)diborane; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Inert atmosphere;

4-(6-chloroimidazo[1,2-a]pyrazin-3-yl)benzonitrile; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In water; N,N-dimethyl-formamide; for 3h; Reflux;

Reference yield:

: 1082604-63-4
4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile

: 1464156-86-2
(4-methylpiperazin-1-yl)(2-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone

: 1464151-16-3
4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In water; N,N-dimethyl-formamide; for 3h; Reflux;

Reference yield:

: 99277-71-1
4-bromo-2-nitrobenzoic acid

: 1464151-16-3
4-(6-(4-(4-methylpiperazine-1-carbonyl)-3-nitrophenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 3 h / Reflux

With 4-methyl-morpholine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; HATU; In water; N,N-dimethyl-formamide;