Technology Process of N-methyl-N-(4-oxocyclohexyl)-2,1,3-benzoxadiazole-5-carboxamide
There total 4 articles about N-methyl-N-(4-oxocyclohexyl)-2,1,3-benzoxadiazole-5-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cyclohexanedione monoethylene ketal; methylamine hydrochloride;
With
hydrogen; triethylamine;
palladium 10% on activated carbon;
In
methanol;
at 20 ℃;
for 2h;
under 2585.81 Torr;
benzofurazan-5-carbonyl chloride;
With
triethylamine;
In
chloroform;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide / ethanol; water / 1.25 h / 65 - 70 °C
1.2: 3.5 h / 0 °C
2.1: triethyl phosphite / ethanol / 70 - 78 °C
3.1: thionyl chloride / toluene / 3 h / Reflux
4.1: triethylamine; hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2585.81 Torr
4.2: 1 h
With
thionyl chloride; hydrogen; triethylamine; potassium hydroxide; triethyl phosphite;
palladium 10% on activated carbon;
In
methanol; ethanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / toluene / 3 h / Reflux
2.1: triethylamine; hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 2585.81 Torr
2.2: 1 h
With
thionyl chloride; hydrogen; triethylamine;
palladium 10% on activated carbon;
In
methanol; toluene;
