<1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester

Base Information

• Chemical Name: <1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester
• CAS No.: 127980-38-5
• Molecular Formula: C₁₈H₂₄O₄
• Molecular Weight: 304.386

Synonyms:<1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester

Chemical Property of <1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester

Chemical Property:

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Technology Process of <1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester

There total 2 articles about <1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

{3-[2-((1S,2R,3R,4R)-3-Acetoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid methyl ester (127980-37-4) → <1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester (127980-38-5)

Guidance literature:

With potassium tert-butylate; In methanol; at 25 ℃; for 2h;

DOI:10.1021/jm00113a030

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + {3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid (1026922-89-3) → <1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester (127980-38-5)

Guidance literature:

In diethyl ether; at 25 ℃; Yield given;

DOI:10.1021/jm00062a013

Reference yield:

<1S-1α,2α,3α,4α>-3-<2-<3-(hydroxymethyl)-7-oxabicyclo<2.2.1>hept-2-yl>ethyl>benzeneacetic acid, methyl ester (127980-38-5) → {3-[2-((1S,2R,3S,4R)-3-Formyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid methyl ester (127980-39-6)

Guidance literature:

With Celite; sodium acetate; pyridinium chlorochromate; In dichloromethane; at 25 ℃; for 1.83333h;

DOI:10.1021/jm00113a030

upstream raw materials:

diazomethane

{3-[2-((1S,2R,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid

{3-[2-((1S,2R,3R,4R)-3-Acetoxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid methyl ester

Downstream raw materials:

[3-(2-{(1S,2R,3S,4R)-3-[(S)-1-(4-Cyclohexyl-butylcarbamoyl)-2-hydroxy-ethylcarbamoyl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

{3-[2-((1S,2R,3S,4R)-3-Formyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-ethyl]-phenyl}-acetic acid methyl ester

[3-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

[3-(2-{(1S,2R,3S,4R)-3-[4-(4-Cyclohexyl-butylcarbamoyl)-4,5-dihydro-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-yl}-ethyl)-phenyl]-acetic acid methyl ester

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