Technology Process of 2-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid
There total 4 articles about 2-hydroxy-4-(2-oxo-5,6-diphenyl-1,2,3,4-tetrahydropyridin-4-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenyl benzyl ketone; 4-formyl-2-hydroxy-benzoic acid methyl ester; ammonium acetate;
With
cycl-isopropylidene malonate; acetic acid;
Reflux;
Inert atmosphere;
With
water; sodium hydroxide;
In
methanol;
at 60 ℃;
for 6h;
Inert atmosphere;
With
hydrogenchloride;
In
methanol; water;
at 20 ℃;
pH=4;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 80 °C / 3750.38 Torr
2.1: aluminum (III) chloride / dichloromethane / 0.05 h / Reflux
3.1: cycl-isopropylidene malonate; acetic acid / Reflux; Inert atmosphere
3.2: 6 h / 60 °C / Inert atmosphere
3.3: 20 °C / pH 4
With
aluminum (III) chloride; 1,1'-bis-(diphenylphosphino)ferrocene; cycl-isopropylidene malonate; palladium diacetate; acetic acid; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: aluminum (III) chloride / dichloromethane / 0.05 h / Reflux
2.1: cycl-isopropylidene malonate; acetic acid / Reflux; Inert atmosphere
2.2: 6 h / 60 °C / Inert atmosphere
2.3: 20 °C / pH 4
With
aluminum (III) chloride; cycl-isopropylidene malonate; acetic acid;
In
dichloromethane;
