isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Base Information

Chemical Name:isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate
CAS No.:1186081-50-4
Molecular Formula:C₂₂H₂₉N₃O₅S
Molecular Weight:447.555
Hs Code.:

Synonyms:isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

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Chemical Property of isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

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Technology Process of isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

There total 4 articles about isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1186081-72-0
2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

: 543-27-1
isobutyl chloroformate

: 1186081-50-4
isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Guidance literature:: 2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride; isobutyl chloroformate; In dichloromethane; at 20 ℃; for 0.0333333h;

With triethylamine; In dichloromethane; at 20 ℃; for 3.25h;

Reference yield:

: 1186081-71-9
tert-butyl 4-[(5-chloropyrazin-2-yl)methoxy]piperidine-1-carboxylate

: 1186081-50-4
isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol; toluene / 20 - 120 °C / Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: dichloromethane / 0.03 h / 20 °C

3.2: 3.25 h / 20 °C

With hydrogenchloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1186081-50-4
isobutyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 18 h / Reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol; toluene / 20 - 120 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

4.1: dichloromethane / 0.03 h / 20 °C

4.2: 3.25 h / 20 °C

With hydrogenchloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol; toluene; 2.1: Suzuki Coupling;