2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

Base Information

Chemical Name:2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride
CAS No.:1186081-72-0
Molecular Formula:C₁₇H₂₁N₃O₃S*ClH
Molecular Weight:383.899
Hs Code.:

Synonyms:2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

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Chemical Property of 2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

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Technology Process of 2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

There total 4 articles about 2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1186081-49-1
tert-butyl 4-({5-[4-(methylsulfonyl)phenyl]pyrazin-2-yl}methoxy)piperidine-1-carboxylate

: 1186081-72-0
2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

Reference yield:

: 105985-21-5
2-chloro-5-pyrazinylmethyl chloride

: 1186081-72-0
2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere

1.2: 18 h / Reflux

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol; toluene / 20 - 120 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 1186081-71-9
tert-butyl 4-[(5-chloropyrazin-2-yl)methoxy]piperidine-1-carboxylate

: 1186081-72-0
2-[4-(methylsulfonyl)phenyl]-5-[(piperidin-4-yloxy)methyl]pyrazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; isopropyl alcohol; toluene / 20 - 120 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; isopropyl alcohol; toluene; 1: Suzuki Coupling;