4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

Base Information

Chemical Name:4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile
CAS No.:1228341-16-9
Molecular Formula:C₁₆H₁₂N₄
Molecular Weight:260.298
Hs Code.:

Synonyms:4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

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Chemical Property of 4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

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Technology Process of 4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

There total 1 articles about 4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 75415-03-1,192777-54-1
2-(1H-pyrazol-3-yl)pyridine

: 17201-43-3
4-cyanobenzyl bromide

: 1228341-16-9
4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 70 ℃; for 20h; Reflux;
DOI:10.1039/b926264d

Reference yield: 53.0%

: 1228341-16-9
4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

: silver nitrate

: Ag⁽¹⁺⁾*NC₅H₄C₃H₂N₂CH₂C₆H₄CN*NO₃^(1-)=(Ag(NC₅H₄C₃H₂N₂CH₂C₆H₄CN)(NO₃))

Guidance literature:: In chloroform; acetonitrile; soln. AgNO3 in MeCN was combined with soln. ligand in chloroform and stirred in the dark for 24 h; solvent was removed in vacuo, residue was washed with MeOH and CHCl3, and dissolved in MeCN, Et2O diffusion; elem. anal.;
DOI:10.1039/b926264d

Reference yield: 46.0%

: silicotungstic acid hexahydrate

: 1228341-16-9
4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile

: 7732-18-5
water

: 6046-93-1
copper(II) acetate monohydrate

: 4C₁₆H₁₂N₄*2Cu⁽²⁺⁾*(SiW₁₂O₄₀)^(4-)

Guidance literature:: silicotungstic acid hexahydrate; 4-[2-(1H-pyrazol-3-yl)pyridyl-1-ylmethyl]benzonitrile; water; copper(II) acetate monohydrate; at 20 ℃; for 0.5h; High pressure;

With hydrogenchloride; at 160 ℃; for 96h; pH=2; Autoclave; High pressure;
DOI:10.1039/d1ce00298h