N,N-Diethyl-2-hydroxyacetamide

Base Information

• Chemical Name: N,N-Diethyl-2-hydroxyacetamide
• CAS No.: 39096-01-0
• Molecular Formula: C6H13 N O2
• Molecular Weight: 131.175
• Hs Code.: 2924199090
• European Community (EC) Number: 626-027-3
• DSSTox Substance ID: DTXSID80399767
• Nikkaji Number: J2.493.438A
• Wikidata: Q82202486
• Mol file: 39096-01-0.mol

Synonyms:N,N-Diethyl-2-hydroxyacetamide;39096-01-0;2-HYDROXY-N,N-DIETHYLACETAMIDE;Acetamide, N,N-diethyl-2-hydroxy-;hydroxyacetic acid diethylamide;glycolic acid diethylamide;SCHEMBL408418;n,n-diethyl-2-hydroxy-acetamide;DTXSID80399767;RZCCQWOCSZOHMQ-UHFFFAOYSA-N;MFCD01863701;AKOS001288283;N,N-Diethyl-2-hydroxyacetamide, 96%;AS-60256;CS-0061509;FT-0717446;W17359;2-chloro-4-((dimethylamino)methyl)-6-methylphenol;Z198152812

Chemical Property of N,N-Diethyl-2-hydroxyacetamide

Chemical Property:

• Vapor Pressure: 0.0216mmHg at 25°C
• Refractive Index: n20/D 1.457(lit.)
• Boiling Point: 238 °C(lit.)
• Flash Point: 220 °F
• PSA: 40.54000
• Density: 1.009 g/mL at 25 °C(lit.)
• LogP: -0.15290
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 131.094628657
• Heavy Atom Count: 9
• Complexity: 89.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Diethyl-2-hydroxyacetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)C(=O)CO
• Uses: N,N-Diethyl-2-hydroxyacetamide is a reactant used in the synthesis of phosphonate prodrugs to increase the oral bioavailability of an antiviral agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA).

Technology Process of N,N-Diethyl-2-hydroxyacetamide

There total 13 articles about N,N-Diethyl-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(benzyloxy)-N,N-diethylacetamide (53056-21-6) → N,N-diethyl-2-hydroxyacetamide (39096-01-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 24h;

Reference yield: 72.0%

4-oxo-2,2-dimethyl-1,3-dioxolane (4158-86-5) + diethylamine (109-89-7) → N,N-diethyl-2-hydroxyacetamide (39096-01-0)

Guidance literature:

In toluene; for 14h; Heating;

DOI:10.1055/s-2007-983762

Reference yield: 56.0%

sodium monochloroacetic acid (3926-62-3) + diethylamine (109-89-7) → N,N-diethyl-2-hydroxyacetamide (39096-01-0)

Guidance literature:

sodium monochloroacetic acid; With triethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; for 20h; Reflux;

diethylamine; at 150 ℃; for 19h; Autoclave;

upstream raw materials:

glycolide

diethylamine

2-acetoxy-N,N-diethylacetamide

C₉H₂₁NO₂Sn

Downstream raw materials:

α-(4-Chlorphenoxy)-isobuttersaeure-diethylcarbamoylmethylester

N,N-diethyl-2-t-butyldiphenylsilyloxy-4-pentenamide

4,5-dichloro-2-thiazolyl-oxyacetic acid N,N-diethylamide

3-phenylfuro[2,3-b]pyridine-2-carboxylic acid diethylamide