3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester

Base Information

• Chemical Name: 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester
• CAS No.: 159432-81-2
• Molecular Formula: C₂₁H₂₄O₈
• Molecular Weight: 404.417
• Mol file: 159432-81-2.mol

Synonyms:3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester

Chemical Property of 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester

There total 2 articles about 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

methyl orsellinate (3187-58-4) + 2,4-Dihydroxy-5-hydroxymethyl-3,6-dimethyl-benzoic acid ethyl ester → 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester (159432-81-2) + 3-(4,6-Dihydroxy-3-methoxycarbonyl-2-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester + C33H38O12

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1016/0040-4039(94)80108-8

Reference yield:

methyl orsellinate (3187-58-4) + ethyl 2,4-dihydroxy-3,6-dimethylbenzoate (31581-32-5) → 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester (159432-81-2)

Guidance literature:

With boron trifluoride diethyl etherate; phenylboronic acid; Yield given. Multistep reaction; 1.) EtCO₂H, toluene, 1 h, reflux, 2.) CHCl₃, -10 deg C, 15 h;

DOI:10.1016/0040-4039(94)80108-8

Reference yield: 78.0%

benzyl bromide (100-39-0) + 3-(2,6-Dihydroxy-3-methoxycarbonyl-4-methyl-benzyl)-4,6-dihydroxy-2,5-dimethyl-benzoic acid ethyl ester (159432-81-2) → 2,4-Bis-benzyloxy-5-(2,6-bis-benzyloxy-3-methoxycarbonyl-4-methyl-benzyl)-3,6-dimethyl-benzoic acid ethyl ester (159432-85-6)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Heating;

DOI:10.1016/0040-4039(94)80108-8

upstream raw materials:

methyl orsellinate

ethyl 2,4-dihydroxy-3,6-dimethylbenzoate

Downstream raw materials:

2,4-Bis-benzyloxy-5-(2,6-bis-benzyloxy-3-methoxycarbonyl-4-methyl-benzyl)-3,6-dimethyl-benzoic acid ethyl ester

C₇₂H₆₈Cl₆O₁₄

2,4-Bis-benzyloxy-5-(2,6-bis-benzyloxy-3-carboxy-4-methyl-benzyl)-3,6-dimethyl-benzoic acid

C₆₈H₆₆O₁₄