phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate

Base Information

• Chemical Name: phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate
• CAS No.: 370861-82-8
• Molecular Formula: C₂₄H₂₂NO₆P
• Molecular Weight: 451.416
• Mol file: 370861-82-8.mol

Synonyms:phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate

Chemical Property of phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate

There total 3 articles about phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chlorophosphoric acid diphenyl ester (2524-64-3) + N-(phenyloxycarbonyl)piperidin-2-one (164732-57-4) → phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate (370861-82-8)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

DOI:10.1039/a804198i

Reference yield:

piperidin-2-one (675-20-7) → phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate (370861-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2: 82 percent / TMEDA; LDA / tetrahydrofuran; heptane / 3 h / -78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane;

DOI:10.1016/S0040-4020(01)00651-2

Reference yield:

phenyl chloroformate (1885-14-9) → phenyl 6-[(diphenoxyphosphoryl)oxo]-3,4-dihydro-1(2H)-pyridinecarboxylate (370861-82-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - 20 °C

2: 82 percent / TMEDA; LDA / tetrahydrofuran; heptane / 3 h / -78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; n-heptane;

DOI:10.1016/S0040-4020(01)00651-2

upstream raw materials:

chlorophosphoric acid diphenyl ester

N-(phenyloxycarbonyl)piperidin-2-one

piperidin-2-one

phenyl chloroformate

Downstream raw materials:

6,7,8,8a-Tetrahydro-3H-1,2-dioxa-5-aza-naphthalene-5-carboxylic acid phenyl ester

6-Vinyl-3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

5,6-Dihydro-4H-pyridine-1,2-dicarboxylic acid 2-methyl ester 1-phenyl ester