Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester
CAS No.:875439-68-2
Molecular Formula:C₄₉H₉₁NO₁₀Si₄
Molecular Weight:966.604
Hs Code.:

Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Synonyms:Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Suppliers and Price of Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

There total 20 articles about Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 875439-60-4
N,O-bis(2-trimethylsilylethoxycarbonyl)-3-amino-5-[(E)-3-iodo-2-methylallyl]-phenol

: 875439-80-8
(E)-(3S,6S,7S,9R,10R)-3,7-Bis-(tert-butyl-dimethyl-silanyloxy)-10-methoxy-4,6-dimethyl-dodeca-4,11-diene-1,9-diol

: 875439-68-2
Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: With tetrabutylammomium bromide; caesium carbonate; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/ol052588q

Reference yield:

: 875439-73-9
3-amino-5-[(E)-3-iodo-2-methylprop-2-enyl]-phenol

: 875439-68-2
Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / pyridine / CH₂Cl₂ / 0 °C

2: 72 percent / tetrabutylammonium bromide; cesium carbonate; triethylamine / Pd(OAc)2 / dimethylformamide / 3 h

With pyridine; tetrabutylammomium bromide; caesium carbonate; triethylamine; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide; 2: Heck reaction;
DOI:10.1021/ol052588q

Reference yield:

: (E)-3-(3-amino-5-hydroxy-phenyl)-2-methyl-prop-1-ene

: 875439-68-2
Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 615 mg / I₂ / 1,2-dichloro-ethane; hexane; tetrahydrofuran / 1 h / -30 °C

2: 89 percent / pyridine / CH₂Cl₂ / 0 °C

3: 72 percent / tetrabutylammonium bromide; cesium carbonate; triethylamine / Pd(OAc)2 / dimethylformamide / 3 h

With pyridine; tetrabutylammomium bromide; iodine; caesium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3: Heck reaction;
DOI:10.1021/ol052588q