Carbonic acid, 3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl] -5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl ester

Base Information

Chemical Name:Carbonic acid, 3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl] -5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl ester
CAS No.:875439-81-9
Molecular Formula:C49H87NO10Si4
Molecular Weight:962.572
Hs Code.:

Carbonic acid,
3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil
yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl]
-5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl
ester

Synonyms:

Suppliers and Price of Carbonic acid, 3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl] -5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Carbonic acid, 3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl] -5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl ester

Chemical Property:

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Safty Information:

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Technology Process of Carbonic acid, 3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl] -5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl ester

There total 22 articles about Carbonic acid, 3-[(2E,4E,6R,9S,10S,11E,13S)-9,13-bis[[(1,1-dimethylethyl)dimethylsil yl]oxy]-6-methoxy-2,10,12-trimethyl-7,15-dioxo-2,4,11-pentadecatrienyl] -5-[[[2-(trimethylsilyl)ethoxy]carbonyl]amino]phenyl 2-(trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 875439-68-2
Carbonic acid 3-[(2E,4E,11E)-(6R,7R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-7,15-dihydroxy-6-methoxy-2,10,12-trimethyl-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

: 875439-81-9
Carbonic acid 3-[(2E,4E,11E)-(6R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-2,10,12-trimethyl-7,15-dioxo-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: With oxalyl dichloride; triethylamine; In dichloromethane; dimethyl sulfoxide; at -60 - -40 ℃;
DOI:10.1021/ol052588q

Reference yield:

: 875439-73-9
3-amino-5-[(E)-3-iodo-2-methylprop-2-enyl]-phenol

: 875439-81-9
Carbonic acid 3-[(2E,4E,11E)-(6R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-2,10,12-trimethyl-7,15-dioxo-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / pyridine / CH₂Cl₂ / 0 °C

2: 72 percent / tetrabutylammonium bromide; cesium carbonate; triethylamine / Pd(OAc)2 / dimethylformamide / 3 h

3: 83 percent / oxalyl chloride; triethylamine / dimethylsulfoxide; CH₂Cl₂ / -60 - -40 °C

With pyridine; oxalyl dichloride; tetrabutylammomium bromide; caesium carbonate; triethylamine; palladium diacetate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Heck reaction;
DOI:10.1021/ol052588q

Reference yield:

: (E)-3-(3-amino-5-hydroxy-phenyl)-2-methyl-prop-1-ene

: 875439-81-9
Carbonic acid 3-[(2E,4E,11E)-(6R,9S,10S,13S)-9,13-bis-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-2,10,12-trimethyl-7,15-dioxo-pentadeca-2,4,11-trienyl]-5-(2-trimethylsilanyl-ethoxycarbonylamino)-phenyl ester 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 615 mg / I₂ / 1,2-dichloro-ethane; hexane; tetrahydrofuran / 1 h / -30 °C

2: 89 percent / pyridine / CH₂Cl₂ / 0 °C

3: 72 percent / tetrabutylammonium bromide; cesium carbonate; triethylamine / Pd(OAc)2 / dimethylformamide / 3 h

4: 83 percent / oxalyl chloride; triethylamine / dimethylsulfoxide; CH₂Cl₂ / -60 - -40 °C

With pyridine; oxalyl dichloride; tetrabutylammomium bromide; iodine; caesium carbonate; triethylamine; palladium diacetate; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 3: Heck reaction;
DOI:10.1021/ol052588q