6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

Base Information

Chemical Name:6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine
CAS No.:1196547-77-9
Molecular Formula:C₂₁H₁₆F₃N₅
Molecular Weight:395.387
Hs Code.:

Synonyms:6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

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Chemical Property of 6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

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Technology Process of 6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

There total 8 articles about 6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025744-38-0
2-fluoro-6-tributylstannanyl-pyridine

: 1196551-98-0
3-bromo-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazine

: 1196547-77-9
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

Guidance literature:: With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 100 ℃; for 6h;

Reference yield:

: (2,5-difluorophenyl)magnesium chloride

: 1196547-77-9
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogenchloride; water / methanol / 6 h / 70 °C

3.1: sodium tetrahydroborate / ethanol / 20 °C

4.1: potassium fluoride / dimethyl sulfoxide / 130 °C

5.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 100 °C

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 399-94-0
2-bromo-1,4-difluorobenzene

: 1196547-77-9
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogenchloride; water / methanol / 6 h / 70 °C

4.1: sodium tetrahydroborate / ethanol / 20 °C

5.1: potassium fluoride / dimethyl sulfoxide / 130 °C

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 100 °C

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; isopropylmagnesium chloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;