1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

Base Information

Chemical Name:1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol
CAS No.:1196547-96-2
Molecular Formula:C₂₆H₂₆F₂N₆O
Molecular Weight:476.529
Hs Code.:

Synonyms:1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

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Chemical Property of 1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

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Technology Process of 1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

There total 9 articles about 1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1196547-77-9
6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazine

: 1196547-96-2
1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

Guidance literature:: With potassium fluoride; In dimethyl sulfoxide; at 110 ℃; for 8h;

Reference yield:

: (2,5-difluorophenyl)magnesium chloride

: 1196547-96-2
1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: hydrogenchloride; water / methanol / 6 h / 70 °C

3.1: sodium tetrahydroborate / ethanol / 20 °C

4.1: potassium fluoride / dimethyl sulfoxide / 130 °C

5.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 100 °C

6.1: potassium fluoride / dimethyl sulfoxide / 8 h / 110 °C

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 399-94-0
2-bromo-1,4-difluorobenzene

: 1196547-96-2
1-(6-(6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperidin-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / -78 - -20 °C / Inert atmosphere

2.1: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: hydrogenchloride; water / methanol / 6 h / 70 °C

4.1: sodium tetrahydroborate / ethanol / 20 °C

5.1: potassium fluoride / dimethyl sulfoxide / 130 °C

6.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 6 h / 100 °C

7.1: potassium fluoride / dimethyl sulfoxide / 8 h / 110 °C

With hydrogenchloride; potassium fluoride; sodium tetrahydroborate; water; isopropylmagnesium chloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;