5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide

Base Information

• Chemical Name: 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide
• CAS No.: 202822-39-7
• Molecular Formula: C₁₅H₁₁ClF₃NO₂
• Molecular Weight: 329.706
• Mol file: 202822-39-7.mol

Synonyms:5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide

Chemical Property of 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide

Chemical Property:

Purity/Quality:

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Technology Process of 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide

There total 3 articles about 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-trifluoromethylphenylamine (455-14-1) + ethyl 5-chloro-2-methoxybenzoate (68216-06-8) → 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide (202822-39-7)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1055/s-2001-16798

Reference yield:

4-trifluoromethylphenylamine (455-14-1) + 2-methoxy-5-chlorobenzoyl chloride (29568-33-0) → 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide (202822-39-7)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 24 ℃; for 18h;

DOI:10.1021/jm010569q

Reference yield:

→ 5-Chloro-2-methoxy-N-[4-(trifluoromethyl)phenyl]benzamide (202822-39-7)

Guidance literature:

upstream raw materials:

4-trifluoromethylphenylamine

ethyl 5-chloro-2-methoxybenzoate

2-methoxy-5-chlorobenzoyl chloride

Downstream raw materials:

C₁₅H₁₁ClF₃NOS

5-(5-Chloro-2-methoxyphenyl)-4-[4-(trifluoromethyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

2-(5-chloro-2-methoxyphenyl)-1-[4-(trifluoromethyl)phenyl]-1H-imidazole