88779-97-9

Usage

Usage

Synthesis of pharmaceutical and agrochemical intermediates

Physical appearance

Pale yellow to brown powder

Melting point

168-170°C

Toxicological properties

Potentially toxic, should be handled with caution in laboratory and industrial settings

Upstream product

• 6968-24-7 2,6-Dibromo-4-methylaniline 
• 544-92-3 copper(I) cyanide 
• 39718-07-5 5-methylbenzene-1,3-dicarbonitrile 
• 78-85-3 2-methylpropenal 
• 109-77-3 malononitrile 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 1311430-85-9 methyl 3,5-bis((tert-butoxycarbonylamino)methyl)-4-(8-hydroxynaphthalen-1-yloxy)benzoate 
• 1311430-78-0 2-iodo-5-methylisophthalonitrile 
• 1311430-80-4 3,5-dicyano-4-iodobenzoic acid 
• 1311430-81-5 methyl 3,5-dicyano-4-iodobenzoate 
• 1311430-82-6 methyl 3,5-dicyano-4-(8-hydroxynaphthalen-1-yloxy)benzoate 
• 68385-96-6 3-methylsulfonylamino-4(2,6-dicyano-4-methylphenyl)azo-N,N-diethylaniline 

Relevant academic research and scientific papers

Synthesis method of disperse red F3BS

The invention discloses a synthesis method of disperse red F3BS. According to the synthesis method, three reaction units for amination, diazotization and coupling are adopted, 5-methylisophthalonitrile is taken as a raw material, acetic acid and polyethylene glycol are taken as mixed solvents, Pd adopting a three-dimensional net-like nanostructure is taken as a catalyst, the mixture has an amination reaction with a hydroxylamine hydrochloride aqueous solution under the assisted catalysis action of a phase transfer catalyst polyethylene glycol, 2,6-dicyano-4-methylaniline is generated, obtained 2,6-dicyano-4-methylaniline has a diazotization reaction under the action of sodium nitrite by taking a hydrochloric acid aqueous solution as a solvent, 2,6-dicyano-4-methylaniline hydrochloride is generated, finally synthesized 2,6-dicyano-4-methylaniline hydrochloride has a coupling reaction under the action of sulfamic acid and N,N-diethyl meta-methanesulfonamide by taking a hydrochloric acid aqueous solution as a solvent, and a target product disperse red F3BS is generated. 2,6-dicyano-4-methylaniline is prepared through direct amination of 5-methylisophthalonitrile, cyanide is not required, the production process is environment-friendly, and the yield is high.

Cleavage of Phosphodiesters and of DNA by a Bis(guanidinium)naphthol Acting as a Metal-Free Anion Receptor

Phosphoric acid diesters form anions at neutral pH. As a result of charge repulsion they are notoriously resistant to hydrolysis. Nucleophilic attack, however, can be promoted by different types of electrophilic catalysts that bind to the anions and reduce their negative charge density. Although in most cases phosphodiester-cleaving enzymes and synthetic catalysts rely on Lewis acidic metal ions, some exploit the guanidinium residues of arginine as metal-free electrophiles. Here we report that a combination of two guanidines and a hydroxy group yields highly reactive receptor molecules that can attack a broad range of phosphodiester substrates by nucleophilic displacement at phosphorus in a single-turnover mode. Some stable O-phosphates were isolated and characterized further by NMR spectroscopy. The bis(guanidinium)naphthols also cleave plasmid DNA, presumably by a transphosphorylation mechanism.

SYNTHESIS OF 4-AMINO-8-CYANOQUINAZOLINES FROM ENONES AND ENALS

The treatment in a sodium methoxide/methanol solution of α,β-unsaturated enones or aldehydes with propanedinitrile in a 1:2 molar ratio led to 2-aminobenzene-1,3-dicarbonitriles.These compounds afforded 4-amino-8-cyanoquinazolines by reaction with formamide or guanidine.

A Simple Synthesis of 2-Methoxypyridine-3-carbonitriles

The condensation of propanedinitrile with several enals or enones in a methanol-sodium methoxide system provides a one-step route to 2-methoxypyridine-3-carbonitriles.Together with these compounds substituted 2-aminobenzene-1,3-dicarbonitriles, were obtained as by-products.

Model Substances for Electro-optical and Dielectric Studies, Part I. Synthesis and Structure of 1,4-Bis(4'-dimethylamino-3',5'-dicyanophenyl)bicyclooctane

A synthesis for a new 1,2,6-donor-acceptor-substituted chromophoric benzene system is given.This chromophore is incorporated in a bicyclooctane system to build up model compounds for electro-optical and dielectrical studies.Furthermore a preparative convenient route to derivatives of 1,4-bis(diphenyl)bicyclooctane is worked out.The structures of the new compounds are proven by spectroscopical means. - Key words: 1,2,6-Donor-Acceptor-Substituted Benzenes, 1,4-Bis(diphenyl)bicyclooctane Derivatives