(2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

Base Information

• Chemical Name: (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate
• CAS No.: 1581734-69-1
• Molecular Formula: C₂₂H₂₉F₃O₄
• Molecular Weight: 414.465

Synonyms:(2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

Chemical Property of (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

There total 11 articles about (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-Methyl-N'-nitro-N-nitrosoguanidine (70-25-7) + (2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate (1581734-68-0) → (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate (1581734-69-1)

Guidance literature:

With palladium diacetate; potassium hydroxide; In diethyl ether; water; at 0 ℃; for 3h;

Reference yield: 81.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (2S,3R)-4-benzyl 1-tert-butyl 2-allyl-3-(3,3,3-trifluoropropyl)succinate (1581734-68-0) → (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate (1581734-69-1)

Guidance literature:

With palladium diacetate; In diethyl ether; water; at 0 ℃; for 3h;

Reference yield: 53.0%

(R)-2-(1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid + benzyl bromide (100-39-0) → (2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate (1581734-69-1) + (2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate (1581735-06-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 5.5h;

upstream raw materials:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

(R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

benzyl bromide

(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Downstream raw materials:

(R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

(2R,3S)-3-(cyclopropylmethyl)-N₁-((R)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

(2S,3R)-tert-butyl 3-((9-bromo-5-(4-chlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamoyl)-2-(cyclopropylmethyl)-6,6,6-trifluorohexanoate

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