(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

Base Information

Chemical Name:(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate
CAS No.:1581735-06-9
Molecular Formula:C₂₂H₂₉F₃O₄
Molecular Weight:414.465
Hs Code.:

Synonyms:(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

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Chemical Property of (2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

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Technology Process of (2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

There total 13 articles about (2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: (R)-2-(1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

: 100-39-0
benzyl bromide

: 1581734-69-1
(2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

: 1581735-06-9
(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 5.5h;

Reference yield: 53.0%

: 1581735-04-7
(R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

: 100-39-0
benzyl bromide

: 1581734-69-1
(2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

: 1581735-06-9
(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 5.5h;

Reference yield:

: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1581735-06-9
(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene; n-heptane / 0.75 h / -78 - 20 °C

1.2: 0.67 h / -78 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 1 h

3.1: potassium hydroxide; palladium diacetate / water; diethyl ether / 3 h / 0 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 2 h

5.1: potassium carbonate / N,N-dimethyl-formamide / 5.5 h

With palladium 10% on activated carbon; hydrogen; palladium diacetate; potassium carbonate; potassium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; n-heptane; ethylbenzene; water; ethyl acetate; N,N-dimethyl-formamide;