2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone

Base Information

• Chemical Name: 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone
• CAS No.: 131303-37-2
• Molecular Formula: C₂₂H₃₂O₆
• Molecular Weight: 392.492
• Mol file: 131303-37-2.mol

Synonyms:2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone

Chemical Property of 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone

There total 3 articles about 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-[2,4,6-trihydroxy-3,5-di(3-methyl-2-buten-1-yl)phenyl]ethanone (35458-19-6) + chloromethyl methyl ether (107-30-2) → 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone (131303-37-2)

Guidance literature:

With potassium carbonate; In acetone; for 0.5h; Heating;

DOI:10.1080/00397919808004863

Reference yield:

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone (65490-09-7) + prenyl bromide (870-63-3) → 2',4'-bis(methoxymethoxy)-5'-(3,3-dimethylallyl)-6'-hydroxyacetophenone (84092-45-5) + 1-[6-hydroxy-2,4-bis(methoxymethoxy)-3-(3-methylbut-2-en-1-yl)phenyl]ethanone (90632-20-5) + 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone (131303-37-2)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 20h;

Reference yield:

prenyl bromide (870-63-3) → 2-hydroxy-3,5-bis(3-methyl-2-butenyl)-4,6-dimethoxymethoxyacetophenone (131303-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / aq. KOH / 1 h / 20 °C

2: 83 percent / K₂CO₃ / acetone / 0.5 h / Heating

With potassium carbonate; In potassium hydroxide; acetone; 1: Substitution / 2: methoxymethylation;

DOI:10.1080/00397919808004863

upstream raw materials:

1-[2,4,6-trihydroxy-3,5-di(3-methyl-2-buten-1-yl)phenyl]ethanone

chloromethyl methyl ether

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

prenyl bromide

Downstream raw materials:

(E)-1-[2-Hydroxy-4,6-bis-methoxymethoxy-3,5-bis-(3-methyl-but-2-enyl)-phenyl]-3-phenyl-propenone

5,7-di(methoxymethoxy)-6,8-di-C-prenyl-4'-O-prenylflavanone

6,8-bis(3-methyl-2-butenyl)-5,7,2',4',6'-pentamethoxymethoxyflavanone

(+/-)-5,7-dihydroxy-6,8-diprenylflavanone