2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

Base Information

Chemical Name:2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine
CAS No.:873323-58-1
Molecular Formula:C₂₄H₃₄ClN₃O₃
Molecular Weight:448.005
Hs Code.:

Synonyms:2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

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Chemical Property of 2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

Chemical Property:

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Technology Process of 2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

There total 5 articles about 2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₃₁ClN₂O₆S

: 124-40-3
dimethyl amine

: 873323-58-1
2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

Guidance literature:: With potassium carbonate; In acetonitrile; at 80 ℃; for 8h;

Reference yield:

: 873324-79-9
[2-(5-bromo-2-chloro-phenoxy)-ethoxy]-tert-butyldimethylsilane

: 873323-58-1
2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 90 °C

2: water; toluene-4-sulfonic acid / tetrahydrofuran / 48 h / Heating / reflux

3: triethylamine / dichloromethane / 1 h / 20 °C

4: potassium carbonate / acetonitrile / 8 h / 80 °C

With potassium tert-butylate; water; potassium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 183802-98-4
5-bromo-2-chlorophenol

: 873323-58-1
2-[(2-chloro-5-{4-[1-(3,4-dimethoxy-phenyl)-ethyl]-piperazin-1-yl}-phenoxy)-ethyl]-dimethyl amine

Guidance literature:: Multi-step reaction with 5 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

2: potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 2 h / 90 °C

3: water; toluene-4-sulfonic acid / tetrahydrofuran / 48 h / Heating / reflux

4: triethylamine / dichloromethane / 1 h / 20 °C

5: potassium carbonate / acetonitrile / 8 h / 80 °C

With di-isopropyl azodicarboxylate; potassium tert-butylate; water; potassium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; triphenylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; acetonitrile; 1: Mitsunobu reaction;