methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

Base Information

Chemical Name:methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate
CAS No.:304682-69-7
Molecular Formula:C₂₅H₃₆N₄O₇
Molecular Weight:504.583
Hs Code.:

methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

Synonyms:methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

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Chemical Property of methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

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Technology Process of methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

There total 2 articles about methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 2133-40-6
L-proline methyl ester monohydrochloride

: 304682-65-3
methyl 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}ethanoate

: 304682-69-7
methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 17h;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield:

: 266338-75-4
2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methylpropanoic acid

: 304682-69-7
methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 15 h / 20 °C

2: 74 percent / O-(1H-benzotriazol-1-yl)-N,N,N',N'-(Me₄)uronium⁽¹⁺⁾ BF₄^(1-); 1-HO-1H-benzotriazole (HOBt); Et₃N / acetonitrile / 17 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; 1: Condensation / 2: Condensation;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G

Reference yield: 98.0%

: 304682-69-7
methyl (S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylate

: 304682-70-0
(S)-1-(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-1-oxoethyl)pyrrolidine-2-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 21h;
DOI:10.1002/1522-2675(20000809)83:8<1881::AID-HLCA1881>3.0.CO;2-G