ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

Base Information

Chemical Name:ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate
CAS No.:136285-02-4
Molecular Formula:C₂₆H₂₅N₇O₂
Molecular Weight:467.53
Hs Code.:

Synonyms:ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

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Chemical Property of ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

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Technology Process of ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

There total 14 articles about ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 136285-01-3
ethyl 2-(chloromethyl)-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

: 74-89-5
methylamine

: 136285-02-4
ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

Guidance literature:: In methanol; acetonitrile; at 60 ℃; for 77h;
DOI:10.1021/jm00067a016

Reference yield:

: ethyl 2-chloromethyl-1-[[2-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7carboxylate

: 136285-02-4
ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

Guidance literature:: With methylamine; In methanol; acetonitrile;

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 136285-02-4
ethyl 2-<(methylamino)methyl>-1-<<2'-(1H-tetrazol-5-yl)biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 12 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 78 percent / ethanol / 1.5 h / Heating

8: 76 percent / CH₂Cl₂ / 2 h / Ambient temperature

9: 99 percent / dimethylformamide / 24 h / Ambient temperature

10: 84 percent / trimethyltin azide / toluene / 29 h / Heating

11: 96 percent / SOCl₂ / CH₂Cl₂ / 3 h / Heating

12: 61 percent / acetonitrile; methanol / 77 h / 60 °C

With hydrogenchloride; thionyl chloride; sodium azide; trimethyltin azide; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016