(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

Base Information

Chemical Name:(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide
CAS No.:1421251-76-4
Molecular Formula:C₃₃H₄₁N₇O
Molecular Weight:551.735
Hs Code.:

Synonyms:(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

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Chemical Property of (R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

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Technology Process of (R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

There total 15 articles about (R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421254-18-3
(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1-tosyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

: 1421251-76-4
(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

Guidance literature:: With ammonium hydroxide; potassium hydroxide; In ethanol; water; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 63028-16-0
5-isopropyl-2-methylphenyl trifluoromethanesulfonate

: 1421251-76-4
(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

2.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

2.2: 0.42 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 125 °C

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.2: 20 h / 20 °C

5.1: ammonium hydroxide; potassium hydroxide / water; ethanol / 1 h / 100 °C / Microwave irradiation

With hydrogenchloride; ammonium hydroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 499-75-2
carvacrol

: 1421251-76-4
(R)-2-(4-(6-(5-isopropyl-2-methylphenyl)-2-(3-methyl-1H-indol-4-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-methylpiperazin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran / 1.5 h / 120 °C / Microwave irradiation; Inert atmosphere; Sealed tube

3.1: hydrogenchloride / water; ethanol / 15 h / 68 °C

3.2: 0.42 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 15 h / 125 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.2: 20 h / 20 °C

6.1: ammonium hydroxide; potassium hydroxide / water; ethanol / 1 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; ammonium hydroxide; palladium diacetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;