4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

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Chemical Name:4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene
CAS No.:1354013-78-7
Molecular Formula:C₄₄H₃₂BF₂N₃O₄
Molecular Weight:715.564
Hs Code.:

Synonyms:4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

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Chemical Property of 4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

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Technology Process of 4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

There total 3 articles about 4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1354013-70-9
4,4-difluoro-2,3,6-triiodo-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indacene

: 87199-17-5
4-formylphenylboronic acid,

: 1354013-78-7
4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; at 75 ℃; for 5h; Sonication;
DOI:10.1016/j.tet.2011.11.070

Reference yield:

: 955084-10-3
5,5-difluoro-10-(p-tolyl)-5H-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinin-4-ium-5-uide

: 1354013-78-7
4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

Guidance literature:: Multi-step reaction with 3 steps

1: Iodine monochloride / methanol; dichloromethane / 6 h / Reflux

2: acetonitrile / 8 h / Reflux; Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 5 h / 75 °C / Sonication

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Iodine monochloride; sodium carbonate; In methanol; 1,2-dimethoxyethane; dichloromethane; acetonitrile; 3: Suzuki coupling;
DOI:10.1016/j.tet.2011.11.070

Reference yield:

: 1354013-80-1
4,4-difluoro-2,3,5,6-tetraiodo-8-(4-methylphenyl)-4-bora-3a,4a-diaza-s-indacene

: 1354013-78-7
4,4-difluoro-2,3,6-(4-formylphenyl)-5-(4-methoxyphenylamino)-8-(4-tolyl)-4-bora-3a,4a-diaza-s-indecene

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 8 h / Reflux; Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane / 5 h / 75 °C / Sonication

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.tet.2011.11.070