tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate
CAS No.:1351940-60-7
Molecular Formula:C₃₈H₃₉ClN₆O₆
Molecular Weight:711.217
Hs Code.:

tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

Synonyms:tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

There total 14 articles about tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193085-24-4
4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 1351940-60-7
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

Guidance literature:: 4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -5 ℃; for 0.333333h;

6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile; With pyridine; In tetrahydrofuran; Cooling with ice;

Reference yield:

: 193085-24-4
4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester

: 1351943-50-4
6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile

: 543-27-1
isobutyl chloroformate

: 1351940-60-7
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

Guidance literature:: 4-carboxymethylenepiperidine-1-carboxylic acid tert-butyl ester; isobutyl chloroformate; With 4-methyl-morpholine; In tetrahydrofuran; at -5 ℃; for 0.333333h;

6-amino-4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-7-(tetrahydrofuran-3-yl-oxy)quinoline-3-carbonitrile; With pyridine; In tetrahydrofuran; Cooling with ice;

Reference yield:

: 1351942-44-3
(E/Z)-ethyl 2-cyano-3-(4-nitro-3-(tetrahydrofuran-3-yl-oxy)-phenylamino)-acrylate

: 1351940-60-7
tert-butyl 4-(2-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7-(tetrahydrofuran-3-yl-oxy)quinolin-6-yl-amino)-2-oxoethylidene)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: biphenyl; diphenylether / 2 h / 256 °C / Inert atmosphere

2.1: trichlorophosphate / 2.5 h / 105 °C / Inert atmosphere

3.1: pyridine hydrochloride / isopropyl alcohol / 2 h / 85 °C

4.1: tin(II) chloride dihdyrate / ethanol / 1.5 h / 85 °C

5.1: isobutyl chloroformate; 4-methyl-morpholine / tetrahydrofuran / 0.33 h / -5 °C

5.2: Cooling with ice

With 4-methyl-morpholine; tin(II) chloride dihdyrate; pyridine hydrochloride; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; diphenylether; biphenyl; ethanol; isopropyl alcohol;