N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

Base Information

Chemical Name:N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide
CAS No.:1039733-08-8
Molecular Formula:C₂₅H₂₂FN₅O₂
Molecular Weight:443.48
Hs Code.:

Synonyms:N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

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Chemical Property of N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

Chemical Property:

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Technology Process of N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

There total 8 articles about N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1039733-00-0
N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

: 141-53-7
sodium formate

: 1039733-08-8
N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

Guidance literature:: With carbon monoxide; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 100 ℃; for 5h; under 760.051 Torr;

Reference yield: 37.0%

: 1039733-00-0
N-[4-({[2-(dimethylamino)-7-iodoquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

: 201230-82-2
carbon monoxide

: 1039733-08-8
N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; sodium formate; In N,N-dimethyl-formamide; at 100 ℃; for 5h; under 760.051 Torr;
DOI:10.1021/jm901370m

Reference yield:

: 959237-34-4
2,4-dichloro-7-iodoquinazoline

: 1039733-08-8
N-[4-({[2-(dimethylamino)-7-formylquinazolin-4-yl]amino}methyl)phenyl]-4-fluorobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 h / 20 °C

2: tetrahydrofuran; water / 26 h / 100 °C

3: carbon monoxide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 5 h / 100 °C / 760.05 Torr

With carbon monoxide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;