tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

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Chemical Name:tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate
CAS No.:1459161-40-0
Molecular Formula:C₂₁H₂₂ClN₃O₆
Molecular Weight:447.875
Hs Code.:

Synonyms:tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

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Chemical Property of tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

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Technology Process of tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

There total 4 articles about tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 75143-76-9,132869-19-3
3-methyl-4-nitro-5-(3-chlorostyryl)isoxazole

: 141293-14-3
N-(tert-butoxycarbonyl)pyrrol-2(5H)-one

: 1459161-40-0
tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: With C₃₂H₂₈F₆N₄O₃; In tetrahydrofuran; at 50 ℃; for 36h; enantioselective reaction;
DOI:10.1039/c3cc44059a

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1459161-40-0
tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride / water; ethanol / 1.5 h / Reflux

2: sulfuric acid; nitric acid / 0 - 20 °C

3: piperidine / ethanol / 65 °C

4: C₃₂H₂₈F₆N₄O₃ / tetrahydrofuran / 36 h / 50 °C

With piperidine; sulfuric acid; C₃₂H₂₈F₆N₄O₃; hydroxylamine hydrochloride; nitric acid; In tetrahydrofuran; ethanol; water; 4: |Michael Addition;
DOI:10.1039/c3cc44059a

Reference yield:

: 300-87-8
3,5-dimethyl-1,2-oxazole

: 1459161-40-0
tert-butyl (2S)-2-((1R)-1-(3-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 0 - 20 °C

2: piperidine / ethanol / 65 °C

3: C₃₂H₂₈F₆N₄O₃ / tetrahydrofuran / 36 h / 50 °C

With piperidine; sulfuric acid; C₃₂H₂₈F₆N₄O₃; nitric acid; In tetrahydrofuran; ethanol; 3: |Michael Addition;
DOI:10.1039/c3cc44059a