(5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol

Base Information

Chemical Name:(5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol
CAS No.:1418197-36-0
Molecular Formula:C₁₉H₁₇F₂NO₄
Molecular Weight:361.345
Hs Code.:

Synonyms:(5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol

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Chemical Property of (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol

Chemical Property:

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Technology Process of (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol

There total 2 articles about (5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1260813-24-8
5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole

: 123-11-5
4-methoxy-benzaldehyde

: 1418197-36-0
(5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol

Guidance literature:: 5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazole; With n-butyllithium; In tetrahydrofuran; at -78 ℃; Inert atmosphere; Schlenk technique;

4-methoxy-benzaldehyde; In tetrahydrofuran; at -78 - 20 ℃; regioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1016/j.jfluchem.2012.11.003

Reference yield:

: 189347-40-8
4,4-difluoro-1-(4-methoxy-phenyl)-butane-1,3-dione

: 1418197-36-0
(5-(difluoromethyl)-3-(4-methoxyphenyl)isoxazol-4-yl)(4-methoxyphenyl)methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sulfuric acid / ethanol / Reflux

2.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere; Schlenk technique

2.2: -78 - 20 °C / Inert atmosphere; Schlenk technique

With n-butyllithium; sulfuric acid; hydroxylamine hydrochloride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.jfluchem.2012.11.003