(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

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Chemical Name:(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate
CAS No.:1396085-99-6
Molecular Formula:C₄₂H₅₀FN₉O₅
Molecular Weight:779.915
Hs Code.:

(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Synonyms:(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

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Technology Process of (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

There total 4 articles about (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: potassium (S)-((4-(tert-butoxycarbonyl)-2-methylpiperazin-1-yl)-methyl)trifluoroborate

: 1253575-94-8
4-(5-chloro-2-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1396085-99-6
(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: With palladium diacetate; caesium carbonate; XPhos; In tetrahydrofuran; water; at 140 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;
DOI:10.1021/jm300846z

Reference yield:

: 147081-29-6
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1396085-99-6
(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran; water / 0.5 h / 140 °C / Microwave irradiation; Inert atmosphere

With palladium diacetate; caesium carbonate; XPhos; In tetrahydrofuran; water;
DOI:10.1021/jm300846z

Reference yield:

: 1253573-75-9
4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1396085-99-6
(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

2: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran; water / 0.5 h / 140 °C / Microwave irradiation; Inert atmosphere

With palladium diacetate; caesium carbonate; lithium hexamethyldisilazane; XPhos; In tetrahydrofuran; water;
DOI:10.1021/jm300846z