(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate
CAS No.:1253575-91-5
Molecular Formula:C₃₈H₄₄FN₉O₅S
Molecular Weight:757.889
Hs Code.:

(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

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Technology Process of (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

There total 6 articles about (S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₄₂FN₉O₃

: 124-63-0
methanesulfonyl chloride

: 1253575-91-5
(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at -15 ℃; for 1h;
DOI:10.1021/jm300846z

Reference yield:

: 147081-29-6
(S)-3-methyl-piperazine-1-carboxylic acid tert-butyl ester

: 1253575-91-5
(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran; water / 0.5 h / 140 °C / Microwave irradiation; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / -15 °C

With palladium diacetate; caesium carbonate; triethylamine; trifluoroacetic acid; XPhos; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm300846z

Reference yield:

: 1253573-75-9
4-(5-chloro-2-fluoropyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253575-91-5
(S)-tert-butyl 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)-pyridin-3-yl)methyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C

2: XPhos; caesium carbonate; palladium diacetate / tetrahydrofuran; water / 0.5 h / 140 °C / Microwave irradiation; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

4: triethylamine / dichloromethane / 1 h / -15 °C

With palladium diacetate; caesium carbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; XPhos; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm300846z