Technology Process of (2R,4S)-4-Methoxy-piperidine-2-carboxylic acid
There total 4 articles about (2R,4S)-4-Methoxy-piperidine-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum(IV) oxide;
In
ethanol; water;
at 60 ℃;
for 24h;
under 3102.9 Torr;
Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00289a058
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 30percent hydrogen peroxide / acetic acid / 24 h / Heating
2: dimethylcarbamyl chloride / CH2Cl2 / 24 h / Ambient temperature
3: 71 percent / 6 N HCl / 24 h / Heating
4: hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr
With
hydrogenchloride; hydrogen; dihydrogen peroxide; N,N-Dimethylcarbamoyl chloride;
platinum(IV) oxide;
In
ethanol; dichloromethane; water; acetic acid;
DOI:10.1021/jo00289a058
- Guidance literature:
-
Multi-step reaction with 3 steps
1: dimethylcarbamyl chloride / CH2Cl2 / 24 h / Ambient temperature
2: 71 percent / 6 N HCl / 24 h / Heating
3: hydrogen / platinum oxide / ethanol; H2O / 24 h / 60 °C / 3102.9 Torr
With
hydrogenchloride; hydrogen; N,N-Dimethylcarbamoyl chloride;
platinum(IV) oxide;
In
ethanol; dichloromethane; water;
DOI:10.1021/jo00289a058
