tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

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Chemical Name:tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate
CAS No.:1447047-13-3
Molecular Formula:C₃₀H₃₈N₂O₆
Molecular Weight:522.642
Hs Code.:

Synonyms:tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

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Chemical Property of tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

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Technology Process of tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

There total 1 articles about tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 21691-53-2
L-leucine tert-butyl ester

: 1359969-23-5
(S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanoic acid

: 1447047-13-3
tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1002/chem.201204260

Reference yield: 60.0%

: 1447047-13-3
tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

: 468065-37-4
methyl 6-azido-2-(boc-amino)hexanoate

: 1447047-16-6
methyl (S)-6-(4-((4-((S)-2-(((benzyloxy)carbonyl)amino)-3-(((S)-1-(tert-butoxy)-4-methyl-1-oxopentan-2-yl)amino)-3-oxopropyl)phenoxy)methyl)-1H-1,2,3-triazol-1-yl)-2-((tert-butoxycarbonyl)amino)hexanoate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In dichloromethane; water; at 20 ℃; for 15h;
DOI:10.1002/chem.201204260

Reference yield:

: 1447047-13-3
tert-butyl (S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(prop-2-yn-1-yloxy)phenyl)propanamido)-4-methylpentanoate

: 1359969-54-2
benzyl N-[(12S,15S,18S)-12-(hydroxymethyl)-15-(2-methylpropyl)-14,17-dioxo-2-oxa-5,6,7,13,16-pentaazatricyclo[18.2.2.1(4,7)]pentacosa-1⁽²²⁾,4⁽²⁵⁾,5,20,23-pentaen-18-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / dichloromethane; water / 15 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide

4: lithium borohydride / tetrahydrofuran; methanol

With lithium borohydride; 1-hydroxy-7-aza-benzotriazole; copper(ll) sulfate pentahydrate; sodium L-ascorbate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/chem.201204260