1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

Base Information

Chemical Name:1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine
CAS No.:1447274-35-2
Molecular Formula:C₂₆H₂₈N₄
Molecular Weight:396.535
Hs Code.:

Synonyms:1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

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Chemical Property of 1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

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Technology Process of 1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

There total 7 articles about 1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1447274-39-6
tert-butyl {1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutyl}carbamate

: 1447274-35-2
1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 7424-54-6
3,5-heptanedione

: 1447274-35-2
1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 4.5 h / 60 °C

2: triethylamine / dichloromethane / 1.17 h / 0 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 0.01 h / 110 °C / Microwave irradiation

4: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1447274-35-2
1-[4-(5,7-diethyl-3-phenylpyrazolo[1,5-a]pyrimidin-2-yl)phenyl]cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium acetate; sodium periodate / acetone / 20 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / N,N-dimethyl-formamide / 0.01 h / 110 °C / Microwave irradiation

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; sodium periodate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; caesium carbonate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;