(3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide

Base Information

• Chemical Name: (3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide
• CAS No.: 1190851-48-9
• Molecular Formula: C₂₂H₁₈Br₂F₄N₂O₂
• Molecular Weight: 578.199

Synonyms:(3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide

Chemical Property of (3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide

Chemical Property:

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Technology Process of (3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide

There total 1 articles about (3Z,4Z)-N₁,N₆-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

N-benzyl-2,2-difluoro-3-butynamide (957109-35-2) → 1-benzyl-3,3-difluoro-5-hydroxypyrrolidin-2-one + (Z)-N-benzyl-4-bromo-2,2-difluoro-3-butenamide (1190851-56-9) + (Z)-N-benzyl-3-(1-benzyl-4-fluoro-2-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-3-yl)-4-bromo-2,2-difluoro-3-butenamide + (3Z,4Z)-N1,N6-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide (1190851-48-9)

Guidance literature:

With gold(III) tribromide; In dichloromethane; at 70 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jo9013436

Reference yield: 85.0%

(3Z,4Z)-N1,N6-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide (1190851-48-9) + sodium methylate (124-41-4) → (3Z,4Z)-N1,N6-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide (1190851-58-1)

Guidance literature:

In tetrahydrofuran; methanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo9013436

Reference yield: 50.0%

(3Z,4Z)-N1,N6-dibenzyl-3,4-bis(bromomethylen)-2,2,5,5-tetrafluorohexanediamide (1190851-48-9) + sodium ethanolate (141-52-6) → (3Z,4Z)-N1,N6-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(ethoxymethylen)hexanediamide (1190851-63-8)

Guidance literature:

In tetrahydrofuran; ethanol; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo9013436

upstream raw materials:

N-benzyl-2,2-difluoro-3-butynamide

Downstream raw materials:

1,1'-dibenzyl-4,4,4',4'-tetrafluoro-1H,1'H-3,3'-bipyrrole-5,5'-dione

(3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(methoxymethylen)hexanediamide

(3Z,4Z)-N₁,N₆-dibenzyl-3-(bromomethylen)-2,2,5,5-tetrafluoro-4-(ethoxymethylen)hexanediamide

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